2026
Protective effect of snail secretion filtrate in an in vitro model of mastitis
Vet Rec Open · 2026 · 13(1):e70027
UniMe Spin-off · Founded 2023
Where Science
meets
Nature
InnovaHelix develops patented natural biocomplexes that revolutionize pharmaceuticals, cosmetics, nutraceuticals and veterinary medicine. Rigorous science, natural ingredients, global impact.
LENIXINA® – Patented
One Health Approach
UniMe Spin-off
About Us
Where Science and Nature Meet
InnovaHelix is an innovative startup and spin-off of the University of Messina, founded in September 2023 by a team of researchers with decades of experience in biology, pharmacology, intellectual property and business development.
01
Rigorous Research
Preclinical validation with international protocols on murine, equine and zebrafish models.
02
Technological Innovation
We transform laboratory discoveries into concrete applications for pharmaceutical, cosmetic and nutraceutical markets.
03
Sustainability & Impact
Natural ingredients, eco-compatible processes and a One Health approach for global ecosystem health.
04
B2B Partnerships
Strategic bridge between academia and market, with technology licensing and custom co-development.
"To discover and valorize the benefits of natural resources to develop innovative solutions that promote global wellbeing and health."
— InnovaHelix Mission
Vision
To become the reference partner for pharmaceutical, cosmetic, nutraceutical and veterinary companies seeking the highest quality, scientifically validated bioactive ingredients ready for industrialization.
Pharmaceutical
Cosmetic
Nutraceutical
Veterinary
Patents & IP
Technology Portfolio
Four patented biocomplexes, scientifically developed and validated, ready for licensing agreements and co-development.
Patent Granted
LENIXINA®
Mucosal regeneration & wound healing
Regenerative bioactive complex for mucosal protection, advanced wound healing and treatment of inflammatory conditions. Validated on murine GERD model.
Snail secretion filtrate
Opuntia extract
Multi-target mechanism: Tissue regeneration · Antioxidant protection · Anti-inflammatory action
PharmaceuticalCosmeticNutraceuticalVeterinary
Patent Granted
N-LENIXINA
Respiratory support & mucolytic
Mucolytic and regenerative formulation for respiratory support. Reduces NAC dosage by 40% while maintaining full therapeutic efficacy.
Snail secretion filtrate
N-Acetylcysteine (NAC)
–40% NAC dose reduction
RespiratoryPharmaceuticalVeterinary
Application Pending
COLIXINA®
Advanced anti-inflammatory with flavonoids
Validated on colitis and systemic inflammation models. Inhibits COX/LOX, controls cytokines (IL-1β, IL-6, TNF-α) with 35% synergistic superiority.
Snail secretion filtrate
Quercetin 10–25%
–65% Mucosal damage+35% Synergy
GastroenterologyNutraceuticalVeterinary
Application Pending
LENEXOL
Neuroprotection & cognitive wellbeing
Neuroprotective complex for cognitive support, reduction of neuroinflammation and wellbeing of the central and peripheral nervous system.
Snail secretion filtrate
Selected bioactive extracts
Targets: Neuroinflammation · Neuronal oxidative stress · Neuroprotection
NeurologyNutraceuticalPharmaceutical
Scientific Publications
PubMed →
PubMed →
PubMed →
PubMed →
Peer-Reviewed Validation
Our research is published in indexed international journals. Every patent is supported by rigorous scientific evidence.
2022
Snail Mucus Filtrate Reduces Inflammation in Canine Progenitor Epidermal Keratinocytes (CPEK)
Animals (Basel) · 2022 · 12(14):1848
2021
The Protective Effect of Snail Secretion Filtrate in an Experimental Model of Excisional Wounds in Mice
Vet Sci · 2021 · 8(8):167
2021
Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
Sci Rep · 2021 · 11(1):3638
Reference Markets
Four Strategic Sectors
Our technologies apply to high-value markets with documented global growth potential.
Pharmaceutical
APIs & Active Ingredients
Patented active ingredients for the treatment of inflammatory conditions, mucosal pathologies and gastrointestinal and respiratory health support.
Cosmetic
Skincare & Dermocosmetics
Anti-aging, regenerative and wound-healing formulations with scientifically validated bioactive ingredients for premium skincare and dermocosmetics.
Nutraceutical
Functional Supplements
Functional supplements for gastrointestinal, immune, joint and anti-aging wellbeing, with documented mechanisms of action.
Veterinary
Pet & Livestock Health
Therapeutic solutions for companion and livestock animals: anti-inflammatory treatments, respiratory support and wound healing.
Integrated Services
What We Offer
From preclinical research to technology transfer, from formulation to scientific marketing.
Preclinical Research & Pharmacology
Comprehensive in vitro and in vivo studies with murine, equine and zebrafish models, following certified international protocols.
- In vitro and in vivo studies (murine, equine, zebrafish)
- Pharmacological and toxicological evaluation
- Efficacy studies for nutraceuticals, cosmetics and medical devices
- Biocompatibility and cytotoxicity testing (ISO 10993)
- Histological, biochemical and molecular analyses
- Inflammation and neuroinflammation models
Natural Formulation Development
From molecule to finished product: screening, development, stability and industrial transfer of innovative natural formulations.
- Screening and characterization of natural biocomplexes
- Innovative formulation development (creams, serums, syrups, supplements)
- Stability, compatibility and synergy studies
- Scale-up support and process transfer
- Drafting of functional and scientific claims
- Regulatory compliance (cosmetics, MD, supplements)
Innovation & Technology Transfer
Strategic support for IP valorization, partnership development and access to national and European funding programmes.
- Patent analysis and mapping (AI-driven)
- Technology economic valorization strategies
- Business modelling and techno-economic validation
- Open Innovation and public-private ecosystems
- Support for European, national and regional calls (Horizon, PNRR, Urban and beyond)
- Digitalization roadmap and AI/IoT adoption
Scientific Marketing & Branding
Strategic positioning and technical-scientific communication for companies pursuing excellence in their market.
- Market analysis and competitive benchmarking
- Brand positioning and scientific branding
- Integrated marketing plans product/price/communication
- Digital marketing and AI marketing
- Technical-scientific copywriting
- Promotional materials and white papers
Scientific Consulting & Dissemination
Comprehensive support from manuscript drafting to scientific communication, from conferences to European dissemination plans.
- Scientific manuscript drafting and review
- Scientific communication for companies and universities
- Conference, workshop and course organization
- Training on pharmacology, nutraceuticals, AI for R&D
- Dissemination plans for European projects and spin-offs
Partnership & Project Management
Coordination of R&D consortia, building strategic partnerships and managing complex European projects.
- Technical-scientific coordination of R&D consortia
- European deliverable, milestone and reporting management
- Industrial partnership building and negotiation
- Project impact and ex-ante/ex-post sustainability analysis
- Industrial and commercial scalability support
Open Innovation
Consulting and European Projects
We support public and private entities in building national and international partnerships for access to funding programmes. InnovaHelix is an active scientific partner for building public-private ecosystems that bring research to real territorial impact.
Are you building a consortium for a European call? Do you have a public or private project requiring scientific and strategic expertise? Contact us.
EU Urban Initiative
Active Project
GreCo — Green Cultural Oases
City of Milazzo (Transfer Partner) · InnovaHelix Strategic Consultant
InnovaHelix supports the Municipality of Milazzo in its role as Transfer Partner in the European GreCO project, funded by the European Urban Initiative – Innovative Actions. The project aims to transform coastal cities into sustainable and regenerative tourism destinations. We support the Municipality in context analysis, operational planning and adaptation of innovative solutions to the Milazzo territory.
Analysis & Planning
Transfer Capacity Survey, territorial SWOT Analysis, local operational roadmap for testing GreCO solutions
Facilitation
Local stakeholder engagement, European deliverable management, coordination with the project Transfer Expert
International Positioning
Milazzo as a Mediterranean reference case for regenerative tourism replicable in other European coastal contexts
"Transforming research into wellbeing, valorizing nature with scientific rigor"
Our Team
People & Expertise
A multidisciplinary team of researchers, IP experts and business developers. Hover over a card to learn more.
SC
Stefano Crupi
CEO & Strategy
SC
Stefano Crupi
CEO & Strategy
Leads company strategy, commercial development and relationships with industrial partners and investors.
stefano@innovahelix.itRC
Rosalia Crupi
Scientific Director
RC
Rosalia Crupi
Scientific Director
Directs scientific research, development of patented complexes and supervision of experimental protocols.
rosalia@innovahelix.itAC
Antonio Crupi
IP & Tech Transfer
AC
Antonio Crupi
IP & Tech Transfer
Responsible for technological innovation, intellectual property, patenting and licensing agreements.
antonio@innovahelix.itEG
Enrico Gugliandolo
R&D Science
EG
Enrico Gugliandolo
R&D Science
Co-leads research and development of patented complexes. New formulations and innovative therapeutic applications.
enrico@innovahelix.itVT
Veronica Trifiletti
Business Development
VT
Veronica Trifiletti
Business Dev. & Partnership
Responsible for developing institutional and public-private partnership opportunities. Liaison with strategic stakeholders.
veronica@innovahelix.it
FAQ
Frequently Asked Questions
InnovaHelix S.r.l. is an innovative startup and spin-off of the University of Messina, founded in 2023. It stands out for original patents on natural biocomplexes with applications in pharmaceutical, cosmetic, nutraceutical and veterinary sectors. The model is based on technology licensing, co-development of formulations and industrial and academic partnerships.
They are innovative formulations derived from natural active ingredients, protected by patents. The portfolio includes LENIXINA® (wound healing), N-LENIXINA (respiratory support), COLIXINA® (anti-inflammatory with bioactive flavonoids) and LENEXOL (neuroprotective). All validated by peer-reviewed scientific studies.
You can collaborate through technology licensing agreements, co-development contracts or scientific partnerships. To start a collaboration, simply contact the team by email at info@innovahelix.it or fill in the contact form. The team responds within 48 business hours.
Yes. InnovaHelix offers co-development of custom formulations for pharmaceutical, cosmetic, nutraceutical and veterinary sectors: chemical and biological validation, regulatory support and production process optimization, with laboratories at the Department of Veterinary Sciences, UniMe.
Technologies apply in: (1) Pharmaceutical — natural active ingredients for OTC and prescription; (2) Cosmetic — bioactive ingredients for anti-aging cosmeceuticals; (3) Nutraceutical — supplements and functional foods; (4) Veterinary — wound healing, anti-inflammatory and immunostimulating products for companion and livestock animals.
InnovaHelix is active within the Horizon Europe and EU Urban Mission programmes. It is available to build consortia with companies, universities and research centres for European calls.
Collaborate With Us
Email
info@innovahelix.it
Let's Build Something Together
Are you a pharmaceutical, cosmetic or nutraceutical company? A research laboratory? An investor? Contact us to explore licensing, co-development and strategic partnership opportunities.
Registered Office
Piazza Municipio, 8
98042 Pace del Mela (ME) — Italy
Operational Office
Dept. of Veterinary Sciences
Polo Universitario dell'Annunziata
98166 Messina
Phone
+39 392 814 6712VAT No.
03760630834